Recent advances in biological applications of nanomaterials through defect engineering

In recent years, defect engineering sprung up in the artificial nanomaterials (NMs) has attracted significant attention, since the physical and chemical properties of NMs could be largely optimized based on the rational control of different defect types and densities. Defective NMs equipped with the improved electric and catalytic ability, would be widely utilized as the photoelectric device and catalysts to alleviate the growing demands of industrial production and environmental treatments. In particular, considering that the features of targeting, adsorptive, loading and optical could be adjusted by the introduction of defects, numerous defective NMs are encouraged to be applied in the biological fields including bacterial inactivation, cancer therapy and so on. And this review is devoted to summarize the recent biological applications of NMs with abundant defects. Moreover, the opportunity of these defective NMs released into the surrounding environment continue to increase, the direct and indirect contact with biological molecules and organisms would be inevitable. Due to its high reactivity and adsorption triggered by defects, NMs tend to exhibit overestimate biological behaviors and effects on organisms. Thus, the sections regarding toxicological effects of NMs with abundant defects are also carried out to supplement the safety assessments of NMs and guide further applications in the industrial production and living.