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Updated: Oct 13, 2025

Osteoclast Derivation from Mouse Bone Marrow
Published on: November 6, 2014
Regulation of bone metabolism mediated by β-adrenergic receptor and its clinical application
Xue-Ping Zhong1, Wen-Fang Xia2
1Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China.
Abstract:
Recent studies have confirmed that β-adrenergic receptors (β-ARs) are expressed on the surface of osteoblasts and osteoclasts, and that the sympathetic nervous system can regulate bone metabolism by activating them. β-AR blockers (BBs) are commonly used in the treatment of cardiovascular diseases in the elderly. It is important to investigate whether BBs have a beneficial effect on bone metabolism in the treatment of cardiovascular diseases, so as to expand their clinical application. This article reviews the effects of BB on bone metabolism and the progress of clinical research.
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