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Updated: Oct 13, 2025

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Published on: August 16, 2018
Enantioselective Copper-Catalyzed Electrophilic Sulfenylation of Cyclic Imino Esters
Zhiwei Chen1,2, Huaxin Lin1,2, Jian Han3
1Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.
Abstract:
Herein we report an enantioselective sulfenylation of cyclic imino esters with the efficient and versatile sulfenylation reagent S-alkyl 4-methylbenzenesulfonothioates. By utilizing the Cu/Bu-Phosferrox catalytic system, we can assemble diverse S-alkyl groups into the cyclic imino esters under mild conditions in good yields and with excellent enantioselectivities. Remarkably, this method demonstrates a high tolerance of diverse functional groups and proves to be applicable in the late-stage functionalization of pharmaceuticals.
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