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Updated: Oct 13, 2025

Using Digital Image Correlation to Characterize Local Strains on Vascular Tissue Specimens
Published on: January 24, 2016
How to standardize measurement of global longitudinal strain
Tomoko Negishi1,2,3, Kazuaki Negishi4,5,6
1Faculty of Medicine and Health, Charles Perkins Centre Nepean, Sydney Medical School Nepean, Nepean Hospital, The University of Sydney, Level 5 South Block, Kingswood, NSW, 2747, Australia.
Abstract:
Global longitudinal strain (GLS) is a robust and sensitive marker of left-ventricular systolic function, reflecting longitudinal shortening of the ventricle. A growing body of evidence indicates its superiority in identifying subclinical, early alterations in cardiac function compared to traditional markers, such as ejection fraction. Therefore, there is a growing demand to assess GLS in clinical settings, but limited availability on how to obtain GLS accurately and appropriately in the current literature. This review summarizes key aspects of GLS measurement, including image acquisition, post-processing, and training/experience needed to facilitate the clinical implication with standardization.
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