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Published on: April 13, 2015
Coronary Flow Velocity Reserve Declines After Anthracycline Therapy in Breast Cancer Patients
Christopher Yu1,2, Prajith Jeyaprakash1,2, Koya Ozawa1,2
1Sydney Medical School, Charles Perkins Centre Nepean, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Abstract:
Anthracycline therapy (ANT) is associated with cancer therapy-related cardiac dysfunction. Coronary flow velocity reserve (CFVR) has shown prognostic utility in non-cancer cohorts, but no data have been obtained in a cardio-oncology setting. We investigated the acute effect of ANT on CFVR in breast cancer patients. A total of 12 female breast cancer patients undergoing ANT had pre- and post-ANT CFVR assessment. A significant decline in CFVR occurred (baseline: 2.66 ± 0.41 vs post-ANT: 2.47 ± 0.37, P = 0.016). This prospective study is the first to identify ANT-related coronary physiology changes in humans. Further studies are required to determine their clinical significance.
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