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Polarization-Resolved Electrochemiluminescence Sensor Based on the Surface Plasmon Coupling Effect of a Au
Peilin Wang1, Junyi Zhao2,3, Zizhun Wang4
1Department of Analytical Chemistry, College of Chemistry, Jilin University, Changchun 130012, China.
Analytical Chemistry
|November 17, 2021
Summary
This study created a novel nanomaterial-patterned structure for enhanced electrochemiluminescence (ECL) detection. The developed biosensor precisely detects miRNA 221, showing promise for diagnosing triple-negative breast cancer.
Area of Science:
- Nanomaterials Science
- Analytical Chemistry
- Biomedical Engineering
Background:
- Surface plasmonic nanomaterials influence electrochemiluminescence (ECL) intensity and polarization.
- Controlling nanomaterial shape and distribution is key for advanced ECL signal modulation.
- Localized surface plasmon resonance and tip amplification effects are crucial for enhancing ECL signals.
Purpose of the Study:
- To construct a nanomaterial-patterned structure for high-resolution ECL signal modulation.
- To develop a polarization-resolved ECL biosensor for sensitive miRNA detection.
- To investigate the impact of hot spot distribution on ECL polarization characteristics.
Main Methods:
- Synthesis of tin disulfide quantum dots as ECL emitters via solvothermal method.
- Construction of self-assembled gold nanotriangle (Au NT)-based patterned structures.
- Design and implementation of a polarization-resolved ECL biosensor for miRNA 221 detection.
Main Results:
- Au NTs exhibited localized surface plasmon resonance and tip amplification effects, creating uniform hot spots.
- The distribution of hot spots on the patterned structure led to directional ECL emission.
- The polarization-resolved biosensor achieved quantitative detection of miRNA 221 in the range of 1 fM to 1 nM.
- Satisfactory results were obtained in analyzing triple-negative breast cancer patient serum samples.
Conclusions:
- Nanomaterial-patterned structures offer precise control over ECL signal modulation and polarization.
- The developed polarization-resolved ECL biosensor demonstrates high sensitivity and specificity for miRNA detection.
- This approach holds significant potential for early diagnosis of diseases like triple-negative breast cancer.
