Transistor-Based Biomolecule Sensors: Recent Technological Advancements and Future Prospects

Area of Science:

• Nanotechnology
• Biomedical Engineering
• Sensor Technology

Background:

• Transistor-based sensors are recognized for high sensitivity and reliability in point-of-care diagnostics.
• Various transistor configurations have been developed for detecting a wide range of clinical biomarkers.
• The field-effect sensitivity of transistors enables high sensitivity for biomolecule detection.

Purpose of the Study:

• To review current achievements and technological advancements in high-performance transistor-based sensors.
• To discuss transistors integrated with functional nanomaterials and organic elements for enhanced selectivity and sensitivity.
• To explore technological advancements in micro/nanodevice fabrication and sensing element functionalization.

Main Methods:

• Review of existing literature on transistor-based biosensors.
• Analysis of technological advancements in materials science and device fabrication.
• Discussion of functionalization strategies for sensing elements.

Main Results:

• Transistors integrated with functional nanomaterials and organic elements show excellent selectivity and sensitivity.
• Technological advancements in micro/nanodevice fabrication and functionalization have been discussed.
• The review identifies a technological gap and scope for future research in transistor platforms.

Conclusions:

• High-performance transistor sensors are crucial for advanced biomolecule detection and diagnostics.
• Further research in fabrication and functionalization will enhance sensor capabilities.
• Future perspectives focus on overcoming technological gaps for broader clinical applications.