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Updated: Oct 13, 2025
Agarose-based Tissue Mimicking Optical Phantoms for Diffuse Reflectance Spectroscopy
Published on: August 22, 2018
Accelerating Monte Carlo simulation of light propagation in tissue mimicking turbid medium based on generative
Shiyuan Wang1, Jiaming Chen1, Fengdi Zhang1
1College of Medicine and Biological information Engineering, Northeastern University, Shenyang, China.
Purpose:
Monte Carlo (MC) simulation is the most frequently used method to numerically model the light propagation in biological tissues because of its high flexibility and precision. Although MC simulation is assumed to be capable of achieving any desired precision, larger number of photons are always necessary for more precise simulation, leading to its major limitation of intensive computation. In this work, the authors present a way to adapt generative adversarial networks (GAN) to accelerate MC simulation.
Methods:
The pix2pix network, a variant of GAN, was investigated to reconstruct precise MC simulation results from the results roughly modeled by small amount of photons, thus the computation time was expected to be significantly saved. The proposed method was tested on single-layer embedded tumor models to derive the absorption distribution maps.
Results:
The results demonstrate that the absorption distribution maps reconstructed from the simulation of only 10 000 photons were very similar to those modeled by using 1 000 000 photons, based on the criterion of peak signal to noise ratio (PSNR) and percentage difference of power coupling efficiencies, and the simulation process was proved to be accelerated by approximately 102 times.
Conclusions:
For the first time, GAN was adapted to save computation time of MC simulation of light propagation. By achieving MC simulation with acceptable quality, the proposed method can speed up the computation by hundreds of times.
