Related Experiment Video

Updated: Oct 13, 2025

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

10.6K

Association of Growth Trajectory Profiles with Asthma Development in Infants Hospitalized with Bronchiolitis

Makiko Nanishi1, Michimasa Fujiogi1, Michelle Stevenson2

  • 1Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Mass.

The Journal of Allergy and Clinical Immunology. in Practice
|November 17, 2021
PubMed

Insights

Infants hospitalized for bronchiolitis with persistent obesity profiles show a significantly higher risk of developing childhood asthma. This risk is amplified in those without allergic predispositions.

Area of Science:

  • Pediatric respiratory health
  • Childhood asthma development
  • Infant growth trajectories

Background:

  • Limited understanding of early-life growth patterns and their link to asthma.
  • Bronchiolitis in infants represents a high-risk population for asthma development.

Purpose of the Study:

  • Identify distinct infant growth trajectory profiles in those hospitalized with bronchiolitis.
  • Determine the longitudinal association between these growth profiles and the risk of childhood asthma.

Main Methods:

  • Multicenter prospective cohort study of infants under 1 year hospitalized for bronchiolitis.
  • Longitudinal clustering analysis of body mass index-for-age from birth to 36 months.
  • Asthma development assessed up to age 5 years.

Main Results:

  • Five growth profiles identified: persistent low growth, normative, transient overweight, late-onset overweight, and persistent obesity.
  • Persistent obesity profile linked to a 2.55-fold increased asthma risk (OR: 2.55, 95% CI: 1.07-6.09).
  • In persistent obesity group, asthma risk was higher without allergic predisposition (ORs: 3.02-3.18).

Conclusions:

  • Distinct infant growth trajectories following bronchiolitis are associated with varying asthma risks.
  • Persistent obesity in infancy is a significant risk factor for childhood asthma.
  • Allergic predisposition may modify the asthma risk associated with infant growth patterns.
Abstract

Keywords:
Allergic predispositionAsthmaBody mass indexChildrenCohortGrowth trajectoryObesity

More Related Videos

Quantified Assessment of Infant's Gross Motor Abilities Using a Multisensor Wearable09:24

Quantified Assessment of Infant's Gross Motor Abilities Using a Multisensor Wearable

Published on: May 17, 2024

1.7K
Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples11:54

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples

Published on: January 21, 2018

31.0K

Related Concept Videos

Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
3.3K
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.7K
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
2.7K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
815
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.8K
Physical Assessment of the Respiratory Tract I: Health History01:28

Physical Assessment of the Respiratory Tract I: Health History

Physical assessment of the respiratory tract is critical to patient care. It allows healthcare professionals to identify and manage various respiratory conditions. The process involves a combination of subjective and objective data collection.
Subjective Data
Subjective data provides vital information about the patient's health history and symptoms. This data is typically collected through interviews in which patients describe their experiences, symptoms, and concerns.
Health history and...
460