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What's new in molecular genetic pathology 2021: solid tumors and NGS panel selection

Guoli Chen1, Patricia C Tsang1

  • 1Geisinger Medical Laboratories, Geisinger Health, Danville and Wilkes-Barre, PA, USA.

Journal of Pathology and Translational Medicine
|November 18, 2021
PubMed

Insights

Molecular genetic and genomic testing is key to precision medicine. Biomarkers aid in accurate cancer diagnosis and predicting treatment response for personalized care.

Area of Science:

  • Oncology
  • Genomics
  • Molecular Diagnostics

Background:

  • Precision medicine relies on molecular genetic and genomic testing.
  • Molecular biomarkers are crucial for accurate cancer diagnosis.
  • These biomarkers predict treatment responses, enabling personalized cancer therapy.

Purpose of the Study:

  • To review current considerations in next-generation sequencing (NGS) panel selection.
  • To discuss molecular testing strategies for solid tumors.
  • To highlight the role of molecular testing in personalized cancer treatment.

Main Methods:

  • Review of current literature and guidelines on NGS panel selection.
  • Analysis of molecular testing approaches for lung, digestive, thyroid, and soft tissue cancers.
  • Discussion of biomarker utility in predicting therapeutic response.

Main Results:

  • NGS panel selection requires careful consideration of target genes and tumor types.
  • Molecular testing of solid tumors provides actionable information for treatment decisions.
  • Biomarker identification is essential for tailoring therapies to individual cancer patients.

Conclusions:

  • Optimized NGS panel selection is vital for effective molecular profiling.
  • Comprehensive molecular testing of solid tumors supports precision oncology.
  • The integration of genomic data improves personalized cancer treatment strategies.

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