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From Progenitors to Progeny: Shaping Striatal Circuit Development and Function.

Rhys Knowles¹, Nathalie Dehorter¹, Tommas Ellender^2,3

¹The John Curtin School of Medical Research, The Australian National University, Canberra 2601, Australian Capital Territory, Australia.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience

|November 18, 2021

Summary

Embryonic progenitor cells in the ganglionic eminences shape striatal neuron development and function. Understanding their diversity is key for treating neurodevelopmental disorders like Huntington's disease and autism spectrum disorder.

Keywords:

basal ganglia embryonic progenitors interneurons lateral ganglionic eminence medial ganglionic eminence neuronal diversity spiny projection neurons striatum

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Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells

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Published on: July 24, 2019

Area of Science:

Neuroscience
Developmental Biology
Cell Biology

Background:

The striatum is crucial for motor control and reward processing.
Its complex circuitry arises from precise neuronal development.
Understanding striatal neuron formation is vital for neurological health and disease insights.

Purpose of the Study:

To review the embryonic origins and development of striatal neurons.
To highlight the role of embryonic progenitors in generating striatal cell diversity.
To connect progenitor characteristics to striatal function and disease.

Main Methods:

Review of existing literature on striatal development.
Focus on embryonic progenitor cells in ganglionic eminences.
Integration of findings from cortical and other brain regions.

Main Results:

Embryonic progenitor origin dictates neuronal identity, location, and connectivity.
Diverse striatal interneurons and projection neurons arise from specific progenitors.
Progenitor dysfunction is linked to Huntington's disease and autism spectrum disorder.

Conclusions:

Embryonic progenitors are central to striatal circuit formation and function.
Understanding progenitor diversity is critical for future research and therapies.
A progenitor-centric view offers new therapeutic avenues for striatal disorders.