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Hyperbaric Oxygen Therapy: An Effective Auxiliary Treatment Method for Large Jaw Cysts
Dou Huang1, Kaide Li1, Xiaohui Zheng1
1State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
International Journal of Medical Sciences
|November 18, 2021
Summary
Hyperbaric oxygen therapy (HBOT) significantly reduces infection rates and enhances bone repair following large jaw cyst removal. This treatment shows promising results for improving patient outcomes after surgical interventions.
Area of Science:
- Oral and Maxillofacial Surgery
- Hyperbaric Medicine
- Regenerative Medicine
Background:
- Large jaw cysts pose significant treatment challenges, often leading to complications like infection and delayed bone healing.
- Current surgical interventions for jaw cysts involve enucleation and bone grafting, with varying success rates.
- The potential benefits of hyperbaric oxygen therapy (HBOT) in managing these complications remain under investigation.
Purpose of the Study:
- To evaluate the efficacy of hyperbaric oxygen therapy (HBOT) in reducing infection rates and improving bone repair after surgical enucleation of large jaw cysts.
- To compare outcomes between patients receiving HBOT, standard bone grafting, and no bone grafting.
- To analyze the impact of HBOT on postoperative complications and bone defect regeneration.
Main Methods:
- A prospective, randomized, controlled clinical trial involving 90 patients with large jaw cysts.
- Patients were divided into three groups: HBOT with bone substitute, bone substitute only (control), and no bone substitute (blank).
- Surgical enucleation was performed, followed by statistical analysis of infection rates, bone repair rates, and patient demographics using Fisher exact test and ANOVA.
Main Results:
- The experimental group receiving HBOT demonstrated a significantly lower infection rate (3.4%) compared to the control (32.1%) and blank (14.3%) groups (P<0.05).
- Bone repair rates were significantly higher in the HBOT group at 1, 3, and 6 months post-surgery compared to the other groups (P<0.05).
- HBOT was associated with improved bone defect regeneration and reduced postoperative complications.
Conclusions:
- Hyperbaric oxygen therapy (HBOT) is an effective adjunctive treatment for large jaw cysts, significantly reducing postoperative infection rates.
- HBOT promotes enhanced bone regeneration and repair following enucleation and bone grafting procedures.
- The findings support the integration of HBOT into the management protocol for large jaw cysts to improve surgical outcomes.
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