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Emphysematous Cystitis in a Patient Receiving Cyclophosphamide
1Department of Medicine, University of Pittsburgh, Pittsburgh, USA.
Cureus
|November 18, 2021
Summary
Emphysematous cystitis (EC), a severe urinary tract infection, is linked to cyclophosphamide therapy in a rare case. This highlights a potential adverse effect of immunosuppressive treatment.
Area of Science:
- Urology
- Nephrology
- Immunology
Background:
- Emphysematous cystitis (EC) is a severe urinary tract infection (UTI) complication.
- Known risk factors include diabetes, urinary obstruction, older age, and female gender.
Observation:
- A patient with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis and rapidly progressive glomerulonephritis (RPGN) developed EC.
- The patient was undergoing induction therapy with intravenous cyclophosphamide.
Findings:
- This case presents a rare instance of EC associated with cyclophosphamide treatment.
- The association between cyclophosphamide and EC has been reported only twice previously in medical literature.
Implications:
- Highlights a potential, rarely reported adverse effect of cyclophosphamide therapy.
- Suggests vigilance for EC in patients receiving cyclophosphamide, particularly those with other risk factors.
- Underscores the importance of considering iatrogenic causes for complicated UTIs in immunocompromised patients.
Keywords:
anca-associated vasculitiscomplicated urinary tract infectioncyclophosphamideemphysematous cystitisimmunosuppressionrapidly progressive glomerulonephritisMore Related Videos
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