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Bowel Perforation During Haemophagocytic Lymphohistiocytosis Treatment with Corticosteroids and Anakinra

Jan Adamski1, Björn Jäschke2, Tuomas Nieminen3

  • 1Department of Anaesthesiology and Intensive Care, Faculty of Medical Sciences, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.

European Journal of Case Reports in Internal Medicine
|November 18, 2021
PubMed

We report the use of anakinra to treat a case of a 64-year-old man diagnosed with haemophagocytic lymphohistiocytosis (HLH) with neurological involvement. After the administration of intravenous pulse corticosteroid therapy, immunoglobulin and anakinra the patient showed neurological recovery. However, the recovery was complicated by the perforation of a pre-existing bowel diverticulum. The effect of anakinra on bowel inflammation has not yet been clearly established. It can potentially augment bowel inflammation and contribute to the risk of bowel perforation associated with the concomitant use of corticosteroids.

Keywords:
Diverticulitisgastrointestinal diseasesguthaemophagocytic lymphohistiocytosis (HLH)interkeukin-1 (IL-1) receptor antagonist

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