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Updated: Oct 13, 2025

Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology
Published on: March 12, 2015
Planar-chiral 1,1'-diaminoferrocenes
Robin Guthardt1, Johannes Blanckenberg1, Clemens Bruhn1
1Institut für Chemie, Universität Kassel, Heinrich-Plett-Straße 40, 34132 Kassel, Germany. siemeling@uni-kassel.de.
Abstract:
Planar-chiral homologues of 1,1'-diaminoferrocene, which bear a single additional substituent adjacent to one of the amino groups, are prepared as racemic mixtures in a few steps and in good yields from ferrocene. Various substituents relevant to steric shielding, coordination and further functionalisation are used, giving access to ferrocene-based planar-chiral diimines and diamines as well as stable N-heterocyclic carbenes and tetrylenes by transformations analogous to procedures established for 1,1'-diaminoferrocene.
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