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Updated: Oct 13, 2025

Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution
Published on: February 24, 2015
[Tobacco and DNA methylation: the case for epigenetic alterations]
Emmanuelle Bouzigon1, Robert Barouki2
1INSERM UMR-S1124, T3S, Toxicologie environnementale, cibles thérapeutiques, signalisation cellulaire et biomarqueurs. Université de Paris, 75006 Paris, France.
Tobacco And Dna Methylation:
THE CASE FOR EPIGENETIC ALTERATIONS The mechanisms of the long-term impacts of exposure to chemical substances remain poorly understood. While genotoxic and mutagenic effects have been well characterized, epigenetic mechanisms such as DNA methylation could also account for the delayed effects of exposures. It is in the case of tobacco that the strongest arguments for a role of these mechanisms have been obtained in human populations. This text presents recent data on this issue demonstrating the plausibility of epigenetic mechanisms to explain the persistence of biological signals long after stopping exposure.
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