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Modification of the cysteamine side chain of thienamycin. III
M Sato1, M Takemura, S Atarashi
1Laboratory of Medicinal Chemistry, Daiichi Seiyaku Co., Ltd., Tokyo, Japan.
The Journal of Antibiotics
|September 1, 1987
Abstract:
Thienamycin derivatives (4) having a cyclic amidine moiety at the C-2 position were prepared. The susceptibility to renal dehydropeptidase-1 and the antimicrobial activity of these compounds were determined. Their structure-activity relationships are also discussed.