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An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

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ACR Appropriateness Criteria® Methodology.

David A Kurth¹, Boaz K Karmazyn², Christine A Waldrip³

¹Senior Director of Guidelines Development, American College of Radiology, Reston, Virginia.

Journal of the American College of Radiology : JACR

|November 19, 2021

Summary

The ACR Appropriateness Criteria® provide evidence-based guidelines for appropriate medical imaging. Their development uses a transparent methodology, ensuring reliable recommendations for clinical scenarios.

Keywords:

AUC Appropriateness Criteria appropriate use criteria clinical practice guidelines methodology

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Area of Science:

Radiology and Medical Imaging
Clinical Practice Guidelines

Background:

Physician imaging orders require evidence-based guidance.
The ACR Appropriateness Criteria® (AC) address this need.

Purpose of the Study:

To describe the methodology behind the ACR Appropriateness Criteria®.
To illustrate adherence to this methodology in AC development.

Main Methods:

Systematic analysis of peer-reviewed medical literature.
Application of Institute of Medicine standards and RAND/UCLA Appropriateness Method.
Utilizing the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.

Main Results:

The October 2020 release includes 198 AC documents covering 1,760 clinical scenarios.
Over 8,815 recommendations were made by 600+ expert members.
Development relied on over 6,200 references.

Conclusions:

The ACR is recognized by CMS as a qualified entity for developing appropriate use criteria.
The described methodology ensures a transparent and rigorous process for creating AC.