Developing Algorithm-Based Recommendations in the ACR: Defining a New Process
Stella K Kang1, Jenny Hoang2, Tarik Alkasab3
1Vice Chair of Research, Professor, Columbia University Irving Medical Center, New York, New York.
Journal of the American College of Radiology : JACR
|November 10, 2025
Summary
A new, formal process for developing algorithm-based imaging recommendations by the American College of Radiology (ACR) has been established. This evidence-driven approach enhances scalability and generalizability for future clinical guidelines.
Area of Science:
- Radiology
- Medical Informatics
- Clinical Guidelines
Background:
- The American College of Radiology (ACR) previously used informal consensus for algorithm-based recommendations, limiting scalability and formal guideline designation.
- The lack of a formal, evidence-driven process hindered incidental findings and other algorithms from meeting the National Academy of Medicine's Trustworthy Guidelines criteria.
- Limited referrer and policymaker adoption was observed due to the absence of a standardized, evidence-based development process.
Purpose of the Study:
- To introduce a new, formal, evidence-driven process for developing algorithm-based imaging recommendations within the ACR.
- To overcome the limitations of the previous informal consensus method, including scalability and generalizability.
- To enable ACR algorithms to meet criteria for designation as clinical guidelines.
Main Methods:
- Formation of a multi-stakeholder committee with ACR approval, including representatives from key ACR committees, commissions, and diverse practice settings.
- Development of a formal, evidence-driven methodology for creating algorithm-based imaging recommendations.
- Ensuring the process is generalizable for adoption by various ACR committees.
Main Results:
- A new, formal, evidence-driven process for algorithm-based imaging recommendations has been successfully developed and documented.
- The new process addresses the limitations of informal consensus, enhancing scalability and generalizability.
- This formalized approach is designed to facilitate compliance with the National Academy of Medicine's Trustworthy Guidelines criteria.
Conclusions:
- The newly developed evidence-driven process provides a robust framework for creating ACR algorithm-based imaging recommendations.
- This formalized process is expected to improve the quality, adoption, and guideline designation of ACR recommendations.
- The methodology is generalizable and can be adopted by other ACR committees for their evidence-based recommendation development.
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