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Undifferentiated Pleomorphic Sarcoma with Neoplastic Fever: A Retrospective Study
Jiaqiang Wang1, Shuping Dong1, Jianpo Zhang2
1Department of Bone and Soft Tissue, the Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, Henan Province, 450008, People's Republic of China.
Cancer Management and Research
|November 19, 2021
Summary
Undifferentiated pleomorphic sarcoma (UPS) with neoplastic fever, a rare subtype, presents with tumor necrosis and edema. These patients show a lower metastasis rate and better survival, suggesting a distinct, potentially more favorable, clinical course.
Area of Science:
- Oncology
- Pathology
- Medical Imaging
Background:
- Undifferentiated pleomorphic sarcoma (UPS) is rare and can present with specific subtypes.
- UPS with neoplastic fever is a distinct subtype with unique clinical features.
- Limited research exists on this specific UPS subtype.
Purpose of the Study:
- To analyze the clinical characteristics of UPS with neoplastic fever.
- To provide diagnostic and therapeutic references for this rare UPS subtype.
Main Methods:
- Retrospective analysis of UPS patient data from June 2012 to June 2018.
- Identification and characterization of patients with neoplastic fever.
- Comparison of clinical features between patients with and without neoplastic fever.
Main Results:
- Seven out of 183 UPS patients (3.83%) presented with neoplastic fever.
- Primary lesions in these patients were in extremities/muscle space.
- MRI revealed intratumoral necrosis and extensive surrounding soft tissue edema.
- Neoplastic fever group had lower metastasis (14.29% vs 44.94%) and higher 3-year survival (85.71% vs 59.55%).
Conclusions:
- UPS with neoplastic fever is characterized by intratumoral necrosis and extensive edema.
- Patients with UPS and neoplastic fever may experience a better prognosis compared to those without.
