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The association between uric acid and erectile dysfunction: A systematic review and Meta-analysis
Xu Wu1, Guodong Liu1, Yuyang Zhang1
1The Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Andrologia
|November 19, 2021
Summary
This study found a significant association between elevated uric acid (UA) and erectile dysfunction (ED). Clinicians should evaluate erectile function in patients with high uric acid levels.
Area of Science:
- Urology
- Nephrology
- Cardiovascular Health
Background:
- Erectile dysfunction (ED) is a common condition with multifactorial causes.
- Elevated uric acid (UA) levels have been implicated in various chronic diseases.
- The specific relationship between UA and ED requires further investigation.
Purpose of the Study:
- To systematically review and meta-analyze existing studies on the association between uric acid and erectile dysfunction.
- To quantify the difference in UA levels between men with ED and healthy controls.
- To determine if UA is an independent risk factor for ED.
Main Methods:
- Systematic literature search of PubMed, Cochrane Library, and Web of Science up to June 31, 2021.
- Data extraction and quality assessment of included studies using the Newcastle-Ottawa Scale (NOS).
- Meta-analysis using standardized mean difference (SMD) to compare UA levels between ED patients and healthy subjects.
Main Results:
- Five studies were included in the meta-analysis.
- A pooled SMD of 0.42 (95% CI: 0.09, 0.74, p < 0.001) indicated significantly higher UA levels in ED patients compared to healthy controls.
- Sensitivity analysis and publication bias assessment did not alter the main findings.
Conclusions:
- Elevated uric acid is confirmed as an independent risk factor for erectile dysfunction.
- This finding suggests a potential link between hyperuricemia and the pathophysiology of ED.
- Clinicians should consider assessing erectile function in individuals with elevated uric acid levels.
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