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Area of Science:

  • Veterinary Dermatology
  • Epidermal Biology
  • Canine Health

Background:

  • The stratum corneum (SC) is the epidermis's outermost layer, essential for skin hydration and environmental protection.
  • Disruptions in SC structure, due to injury or genetic defects, compromise skin barrier function, leading to dehydration, infections, and allergies.
  • Veterinary dermatology recognizes diverse diseases stemming from SC abnormalities, affecting structural proteins, enzymes, or lipids.

Purpose of the Study:

  • To review and discuss various forms of ichthyosis in dogs.
  • To highlight the role of SC structure and function in canine dermatological diseases.
  • To provide insights into conditions mimicking human diseases and those unique to canines.

Main Methods:

  • Literature review of veterinary dermatology studies.
  • Analysis of research on SC structure, function, and associated diseases in dogs.
  • Synthesis of information on canine ichthyosis and related genetic defects.

Main Results:

  • Canine ichthyosis encompasses a spectrum of disorders arising from SC defects.
  • These defects involve structural proteins, enzymes, or lipids critical for corneocyte and lipid bilayer formation.
  • Some canine SC disorders parallel human conditions, while others are specific to dogs.

Conclusions:

  • Understanding SC structure and function is crucial for diagnosing and managing canine dermatological diseases.
  • Ichthyosis in dogs represents a significant group of disorders linked to impaired skin barrier.
  • Further research into genetic and molecular underpinnings of canine ichthyosis is warranted.