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A new anthracycline regimen for prolymphocytic leukemia? Study of a case report with flow cytometric implications
F Franchi1, P Seminara, G Codacci-Pisanelli
13rd Department of Internal Medicine, University of La Sapienza, Roma, Italy.
Abstract:
A case of prolymphocytic leukemia (PL) is reported, which showed a good response to a new antiblastic schedule (4-epidoxorubicin-asparaginase-dexamethasone) in spite of the resistance to other chemotherapy regimens. However during the course of the disease it was possible to observe the terminal appearance of a small aneuploid cell population in the peripheral blood of the patient and, in the same time, the clinical condition deteriorated considerably. The significance of this neoplastic progression and the pros and cons of aggressive chemotherapy regimens remain to be carefully evaluated in PL and related disorders.