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Mesoporous Bioactive Glasses in Cancer Diagnosis and Therapy: Stimuli-Responsive, Toxicity, Immunogenicity, and
Esmaeel Sharifi1,2, Ashkan Bigham2, Satar Yousefiasl3
1Department of Tissue Engineering and Biomaterials, School of Advanced Medical Sciences and Technologies, Hamadan University of Medical Sciences, Hamadan, 6517838736, Iran.
Abstract:
Cancer is one of the top life-threatening dangers to the human survival, accounting for over 10 million deaths per year. Bioactive glasses have developed dramatically since their discovery 50 years ago, with applications that include therapeutics as well as diagnostics. A new system within the bioactive glass family, mesoporous bioactive glasses (MBGs), has evolved into a multifunctional platform, thanks to MBGs easy-to-functionalize nature and tailorable textural properties-surface area, pore size, and pore volume. Although MBGs have yet to meet their potential in tumor treatment and imaging in practice, recently research has shed light on the distinguished MBGs capabilities as promising theranostic systems for cancer imaging and therapy. This review presents research progress in the field of MBG applications in cancer diagnosis and therapy, including synthesis of MBGs, mechanistic overview of MBGs application in tumor diagnosis and drug monitoring, applications of MBGs in cancer therapy ( particularly, targeted delivery and stimuli-responsive nanoplatforms), and immunological profile of MBG-based nanodevices in reference to the development of novel cancer therapeutics.
Insights
Mesoporous bioactive glasses (MBGs) show promise for cancer theranostics, offering advanced imaging and drug delivery. Further research highlights their potential in novel cancer therapeutics and diagnostics.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Oncology
Background:
- Cancer remains a leading cause of mortality, driving the need for innovative therapeutic and diagnostic strategies.
- Bioactive glasses have evolved significantly, with mesoporous bioactive glasses (MBGs) emerging as versatile platforms due to their tunable properties.
- MBGs offer a multifunctional approach for cancer management, integrating therapeutic and diagnostic capabilities.
Purpose of the Study:
- To review the recent advancements in mesoporous bioactive glasses (MBGs) for cancer diagnosis and therapy.
- To explore the synthesis, mechanistic applications, and therapeutic potential of MBGs in oncology.
- To discuss the immunological aspects of MBG-based nanodevices for novel cancer treatment development.
Main Methods:
- Review of current research on MBG synthesis and characterization.
- Analysis of MBG mechanisms in tumor diagnosis, drug monitoring, and targeted delivery.
- Evaluation of MBG applications in stimuli-responsive nanoplatforms and immunological profiling.
Main Results:
- MBGs possess tailorable textural properties (surface area, pore size, pore volume) and are easily functionalized.
- MBGs demonstrate significant potential as theranostic systems for cancer imaging and therapy.
- Research indicates MBGs can be engineered for targeted drug delivery and stimuli-responsive release.
Conclusions:
- Mesoporous bioactive glasses represent a promising frontier in theranostic applications for cancer.
- MBGs offer a versatile platform for developing advanced cancer imaging, drug delivery, and therapeutic strategies.
- Further investigation into MBG-based nanodevices, including their immunological profiles, is crucial for clinical translation.
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