Reversible structure transformation between protein nanocages and nanorods controlled by small molecules

Constructing different protein nanostructures by using identical building blocks, while realizing their structural transformation in response to external stimuli, remains a challenge. Here, we fabricated protein nanocages and nanorods by using dimeric TmFtn as a building block and reacting with Mg²⁺/(α, L-lysine) with polymerization degrees of 9 (PLL₉) and 15 (PLL₁₅), respectively. Notably, the reversible shape transformation of these two supramolecular protein architectures with different dimensions can be achievable in response to external stimuli.