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Photodynamic Therapy with Blended Conducting Polymer/Fullerene Nanoparticle Photosensitizers
Published on: October 28, 2015
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A targeted self-assembling photosensitizer nanofiber constructed by multicomponent coordination
Qianqian Zhang1, Jiawei Xu1, Jiayi Peng1
1The National and Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, China. liuzh@hunnu.edu.cn.
Biomaterials Science
|November 19, 2021
Summary
Researchers developed novel peptide-based nanofibers for photodynamic therapy (PDT). These nanofibers enhance drug delivery and cancer cell killing, showing promise for improved anticancer efficiency.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Cancer Therapy
Background:
- Peptide-based supramolecular photosensitizers offer precise control in photodynamic therapy (PDT).
- Developing multifunctional nanofibers can improve drug delivery and therapeutic outcomes.
Purpose of the Study:
- To create a versatile, multicomponent, self-assembling photosensitizer nanofiber for enhanced PDT.
- To evaluate the efficacy of the developed nanofibers in cancer treatment.
Main Methods:
- Fabrication of CPP44-FF-TPP-NH2 nanofibers (CFTNFs) using diphenylalanine peptide, cell penetrating peptide 44, and a porphyrin photosensitizer.
- Characterization of nanofiber morphology using transmission electron microscopy.
- Assessment of cell uptake, tumor targeting, and anticancer effects (apoptosis, necrosis, tumor growth inhibition) both in vitro and in vivo.
Main Results:
- CFTNFs displayed a filamentous morphology.
- CFTNFs showed significantly higher cell uptake in HepG2 cells compared to free photosensitizer.
- In vivo studies demonstrated enhanced tumor targeting and greater tumor growth inhibition with CFTNFs.
Conclusions:
- CFTNFs represent a promising platform for enhancing photodynamic therapy efficacy.
- The developed peptide-based nanofibers offer improved tumor-specific delivery and anticancer activity.
