Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Molecular clock rates at loci under stabilizing selection.

P Foley1

  • 1Department of Genetics, University of California, Davis 95616.

Proceedings of the National Academy of Sciences of the United States of America
|November 1, 1987
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real-World Efficacy and Drug Survival of Adalimumab in Australian Patients With Psoriasis.

The Australasian journal of dermatology·2026
Same author

Development of an Australasian Dermatology Registry.

The Australasian journal of dermatology·2025
Same author

Immunogenicity and pharmacokinetics of guselkumab among patients with moderate-to-severe psoriasis in VOYAGE-1 and VOYAGE-2.

Journal of the European Academy of Dermatology and Venereology : JEADV·2023
Same author

Super-response to guselkumab treatment in patients with moderate-to-severe psoriasis: age, body weight, baseline Psoriasis Area and Severity Index, and baseline Investigator's Global Assessment scores predict complete skin clearance.

Journal of the European Academy of Dermatology and Venereology : JEADV·2022
Same author

Guidelines for the peri-operative management of people with cardiac implantable electronic devices: Guidelines from the British Heart Rhythm Society.

Anaesthesia·2022
Same author

Ixekizumab provides persistent improvements in health-related quality of life and the sexual impact associated with moderate-to-severe genital psoriasis in adult patients during a 52-week, randomised, placebo-controlled, phase 3 clinical trial.

Journal of the European Academy of Dermatology and Venereology : JEADV·2021
Same journal

Chemotactic self-organization captures the dynamics of mammalian hair follicle patterning.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Tomographic imaging of superconducting order using particle-hole interference.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Inhibitory potential of autologous neutralizing antibodies sets quantitative limits on the rebound-competent HIV-1 reservoir.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Inferring epidemiological parameters under an infectious phylogeography model with visitor dynamics.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Analytical modeling for suction cup designs for skin-interfaced wearable devices.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Improving cell-free metabolism through direct integration of artificial respiratory chains.

Proceedings of the National Academy of Sciences of the United States of America·2026
See all related articles

The rate of allelic substitutions (lambda) in finite populations under stabilizing selection is influenced by mutation rate (mu) and selection stringency (S). Population size plays a key role in substitution rates, aligning with nearly neutral theory.

Area of Science:

  • Population genetics
  • Molecular evolution
  • Theoretical biology

Background:

  • Allelic substitutions drive evolutionary change.
  • Understanding factors influencing substitution rates is crucial for evolutionary studies.

Purpose of the Study:

  • To derive and validate a formula for the rate of allelic substitutions under stabilizing selection in finite populations.
  • To explore the relationship between substitution rates, mutation, selection, and population size.

Main Methods:

  • Utilized the Crow and Kimura model of a continuum of alleles with Gaussian selection and mutation.
  • Employed Monte Carlo simulations to corroborate the derived formula.

Main Results:

  • Developed an approximation for the rate of allelic substitutions: lambda approximately mu(1 + S)-1/2.

Related Experiment Videos

  • The formula holds for both isolated (lonely) and interacting (embedded) loci.
  • Demonstrated the significant role of population size (N) in determining substitution rates.

    • Conclusions:

    • The derived formula provides a framework for estimating population genetics parameters from molecular evolution data.
    • Findings support the importance of population size in evolutionary substitution processes, consistent with nearly neutral theory.