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Osteoarthritis in year 2021: biochemical markers
1musculoSKeletal Innovative research Lab (mSKIL), Institute of Pathology, Level 5, CHU Sart-Tilman, Center for Interdisciplinary Research on Medicines (CIRM), Department of Motricity Sciences, University of Liège, Belgium; Department of Physical Therapy and Rehabilitation, Princess Paola Hospital, Vivalia, Marche-en-Famenne, Belgium.
Osteoarthritis and Cartilage
|November 19, 2021
Summary
Recent advances in protein-derived biomarkers for osteoarthritis are reviewed. Research focuses on identifying patient subgroups and improving clinical trial monitoring for targeted osteoarthritis management.
Area of Science:
- Biochemistry
- Orthopedics
- Biomarker Research
Background:
- Osteoarthritis (OA) diagnosis and management require improved tools.
- Protein-derived soluble biomarkers offer potential for objective assessment.
Purpose of the Study:
- To summarize recent scientific advances in protein-derived soluble biomarkers for osteoarthritis.
- To review the clinical significance and applications of these biomarkers.
Main Methods:
- Systematic literature search of PubMed (Jan 2020 - Mar 2021).
- Selection of studies based on objective criteria.
- Narrative review and classification of selected papers by clinical significance (BIPEDS).
Main Results:
- 16 studies were included in the narrative review from 1971 initial publications.
- Biomarkers were evaluated for disease burden, investigative potential, prognosis, treatment efficacy, and diagnosis/phenotyping.
- Specific applications included identifying molecular endotypes and clinical phenotypes.
Conclusions:
- Biomarker research is crucial for identifying patient subgroups in osteoarthritis.
- Protein-derived biomarkers aid in patient screening and monitoring within clinical trials.
- This facilitates more targeted management strategies for osteoarthritis patients.
