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Metabolic Dysfunction-Associated Fatty Liver Disease and Subsequent Development of Adverse Pregnancy Outcomes

Seung Mi Lee1, Young Mi Jung1, Eun Saem Choi1

  • 1Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
|November 19, 2021
PubMed
Abstract

Insights

Metabolic dysfunction-associated fatty liver disease (MAFLD) significantly increases the risk of adverse pregnancy outcomes in expectant mothers. This finding highlights MAFLD as a critical factor in maternal health during pregnancy.

Area of Science:

  • Hepatology
  • Obstetrics
  • Metabolic Disorders

Background:

  • Metabolic dysfunction-associated fatty liver disease (MAFLD) is proposed as a more accurate descriptor than nonalcoholic fatty liver disease (NAFLD) for liver conditions linked to metabolic dysfunction (MD).
  • Investigating the impact of MAFLD on pregnancy complications is crucial for understanding maternal and fetal health risks.

Purpose of the Study:

  • To investigate the association between MAFLD and adverse pregnancy outcomes.
  • To compare the risks associated with MAFLD, non-MD NAFLD, and no NAFLD in pregnant women.

Main Methods:

  • Secondary analysis of a multicenter prospective cohort study.
  • Evaluation of hepatic steatosis via liver ultrasonography and biochemical measurements in the first trimester.
  • Categorization of pregnant women into three groups: no NAFLD, non-MD NAFLD, and MAFLD.

Main Results:

  • The study included 1744 pregnant women: 1523 with no NAFLD, 43 with non-MD NAFLD, and 178 with MAFLD.
  • MAFLD was associated with a significantly higher risk of adverse pregnancy outcomes compared to non-MD NAFLD (aOR, 4.03; 95% CI, 1.68-9.67).
  • Women with MAFLD faced higher risks than those with no NAFLD, irrespective of metabolic dysfunction status.

Conclusions:

  • MAFLD is linked to an elevated risk of adverse pregnancy outcomes in pregnant women.
  • The findings support MAFLD as a distinct clinical entity with significant implications for pregnancy health.
Keywords:
Adverse Pregnancy OutcomesGestational Diabetes MellitusMetabolic Dysfunction–Associated Fatty Liver DiseaseNonalcoholic Fatty Liver Disease

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