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Published on: May 17, 2024
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Cross-sectional study: Relationship between serum trace elements and hypertension.
Zhengduo Zhang1, Shuyong Zhao2, Hong Wu1
1Department of Physical and Chemical Inspection, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.
Summary
Hypertension is linked to specific trace element levels and ratios in rural Chinese adults. Higher serum copper (Cu), selenium (Se), and certain element ratios like Cu:Zn may be associated with increased hypertension risk.
Area of Science:
- Nutritional Science
- Cardiovascular Health
- Epidemiology
Background:
- Trace element balance is crucial for managing chronic diseases like hypertension.
- Limited data exists on specific trace elements and their ratios independently associated with hypertension.
Purpose of the Study:
- To investigate the association between serum trace element levels, their ratios, and hypertension in a rural Chinese population.
- To explore age- and sex-related differences in trace element concentrations among hypertensive and control groups.
Main Methods:
- A large-scale study of 6,754 rural Chinese adults, employing multi-stage sampling.
- Measurement of 12 serum trace elements using advanced spectrometry techniques (flame atomic absorption and ICP-MS).
- Analysis of blood pressure, basic information via questionnaires, and biochemical indicators.
Main Results:
- Significant differences observed in serum levels of magnesium, iron, copper, boron, selenium, and chromium between hypertensive and control groups.
- Serum copper (Cu), selenium (Se), and chromium (Cr) showed independent associations with hypertension (ORs: 1.36, 1.03, 0.89 respectively).
- Elevated serum copper/zinc (Cu:Zn) and magnesium/manganese (Mg:Mn) ratios were associated with increased odds of hypertension (ORs: 1.22, 1.20 respectively).
Conclusions:
- Serum trace element levels exhibit age- and sex-specific variations in relation to hypertension.
- Serum Cu, Se, and Cr concentrations, along with Cu:Zn and Mg:Mn ratios, may be independently linked to hypertension.
- Further randomized trials are needed to confirm the causal relationship between these elements/ratios and hypertension.
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