[Detection of Subclinical Keratoconus]

The early stage of a keratoconus (KC), without classic and characteristic clinical findings, is a contraindication for refractive surgery. This article therefore shows, in accordance with the current state of the art, ways of identifying risk factors for subclinical keratoconus.After delimitation, this publication contains a current summary of epidemiology, etiology and pathophysiology of subclinical and clinical KC. Furthermore, an overview of different grading scales is given. A detailed description of several practical possibilities for detection of subclinical KC is the focus of this publication: typical abnormalities with subclinical KC in ocular aberrometry, corneal topography, Zernike analysis, Fourier analysis, indices of the corneal anterior surface; especially tomography of the anterior segment of the eye respecting addition of the corneal posterior surface and the pachymetry, and also innovative techniques counting in the rigidity or biomechanical properties, as well as traditional techniques giving hints for subclinical KC as retinoscopy, ophthalmoscopy and subjective refraction.In preparation for refractive surgical interventions and to avoid possible consequences of subclinical KC, a suitable analysis with different methods should always be carried out in addition to a specific anamnesis. An exclusive consideration of the available indices is not sufficient, as this does not reveal early stages. Ideally, the biomechanics of the cornea is included in the diagnosis. The combination of tomography and biomechanics with methods of artificial intelligence are trendsetting in detection of subclinical KC.