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Atomically precise silver clusterzymes protect mice from radiation damages.

Jiao Guo1, Haiyu Yang1, Ya Liu1

  • 1Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300192, China.

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Summary

Atomically precise silver (Ag14) clusterzymes show promise as radioprotective agents. These ultrasmall molecules effectively protect normal tissues from radiation damage in vitro and in vivo with minimal toxicity.

Keywords:
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Area of Science:

  • Nanotechnology
  • Radiochemistry
  • Biomedical Engineering

Background:

  • Radiotherapy is crucial for solid tumors but causes collateral damage to healthy tissues.
  • Developing efficient radioprotective agents with low toxicity is a significant clinical need.
  • Atomically precise silver (Ag14) clusterzymes are explored for radioprotection.

Purpose of the Study:

  • To synthesize and characterize atomically precise Ag14 clusterzymes.
  • To evaluate their radioprotective efficacy in vitro and in vivo.
  • To assess their safety and biodistribution.

Main Methods:

  • Synthesis of Ag14 clusterzymes using sodium borohydride reduction.
  • Assessment of enzyme-like activity and antioxidant capacity (SOD-like, •OH scavenging).
  • In vitro cell viability assays post-irradiation.
  • In vivo studies in mice for survival, biodistribution, and toxicity.

Main Results:

  • Ag14 clusterzymes demonstrated significant superoxide dismutase (SOD)-like activity and •OH scavenging.
  • They improved cell viability by reducing reactive oxygen species (ROS) and DNA damage.
  • In vivo, they enhanced survival rates, protected hematological systems, and repaired oxidative stress.
  • Ultrasmall Ag14 clusterzymes were rapidly excreted renally with negligible toxicity.

Conclusions:

  • Atomically precise, ultrasmall Ag14 clusterzymes are effective radioprotectants in vitro and in vivo.
  • Their SOD-like activity and antioxidant properties contribute to radioprotection.
  • Potential for structural optimization of Ag14 clusterzymes for broader therapeutic and diagnostic applications.