Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Discovery: Overview01:26

Drug Discovery: Overview

9.4K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
9.4K
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

11
Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
11
Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems01:22

Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems

13
Body:Bioavailability is a critical pharmacological concept that measures the extent and rate at which an active drug ingredient or therapeutic moiety enters the systemic circulation, remaining unchanged. It's a pivotal factor in determining a drug's efficacy and safety.The Biopharmaceutics Classification System (BCS) plays an essential role in drug development by categorizing drugs into four classes based on their solubility and permeability. This classification aids in understanding drug...
13
Preclinical Development: Overview01:28

Preclinical Development: Overview

5.1K
Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
5.1K
Bioavailability Enhancement: Drug Solubility Enhancement01:16

Bioavailability Enhancement: Drug Solubility Enhancement

8
Body:Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
8
Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

13
Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
13

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structured Electrodes Enable High-Rate and Selective Electrochemical Nicotinamide Adenine Dinucleotide Regeneration for Biocatalysis.

ChemSusChem·2026
Same author

A Click-Type Reaction of (RRR)-α-Tocopherol and Related 6-Chromanols Allowing a One Pot Derivatisation of All Fat-Soluble Vitamins.

Chemistry (Weinheim an der Bergstrasse, Germany)·2025
Same author

Bringing Attomolar Detection to the Point-of-Care with Nanopatterned DNA Origami Nanoantennas.

Advanced materials (Deerfield Beach, Fla.)·2025
Same author

Way Forward for Biomanufacturing and Biotechnology in Europe.

Chimia·2025
Same author

Deconjugative Photoisomerization of Cyclic Enones.

Journal of the American Chemical Society·2025
Same author

Over 100 years of vitamin E: An overview from synthesis and formulation to application in animal nutrition.

Journal of animal physiology and animal nutrition·2024

Related Experiment Video

Updated: Oct 12, 2025

Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology
06:24

Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology

Published on: December 15, 2017

10.3K

A Decade of Successful Collaborations in Nutritional Compound Process Research and Development.

Werner Bonrath1, Roman Goy1, Ulla Létinois1

  • 1DSM Nutritional Products, Chemical Process Research and Development, PO Box 2676, CH-4002 Basel, Switzerland.

Chimia
|November 20, 2021
PubMed
Summary

Academic and industry collaborations accelerate sustainable chemical process development. This summary highlights successful partnerships between DSM Nutritional Products and Swiss academic institutions, yielding new synthetic routes and improved catalysts.

More Related Videos

Author Spotlight: Optimization of Processing Technology for Tiebangchui with Zanba Based on CRITIC Combined with Box-Behnken Response Surface Method
09:16

Author Spotlight: Optimization of Processing Technology for Tiebangchui with Zanba Based on CRITIC Combined with Box-Behnken Response Surface Method

Published on: May 12, 2023

1.3K
Scaled-Up Preparation of an Intermediate of Upatinib, ACT051-3
08:36

Scaled-Up Preparation of an Intermediate of Upatinib, ACT051-3

Published on: April 7, 2023

1.3K

Related Experiment Videos

Last Updated: Oct 12, 2025

Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology
06:24

Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology

Published on: December 15, 2017

10.3K
Author Spotlight: Optimization of Processing Technology for Tiebangchui with Zanba Based on CRITIC Combined with Box-Behnken Response Surface Method
09:16

Author Spotlight: Optimization of Processing Technology for Tiebangchui with Zanba Based on CRITIC Combined with Box-Behnken Response Surface Method

Published on: May 12, 2023

1.3K
Scaled-Up Preparation of an Intermediate of Upatinib, ACT051-3
08:36

Scaled-Up Preparation of an Intermediate of Upatinib, ACT051-3

Published on: April 7, 2023

1.3K

Area of Science:

  • Industrial Chemistry
  • Sustainable Chemical Processes
  • Catalysis

Background:

  • Academia-industry collaborations are crucial for industrial research and development.
  • DSM Nutritional Products has a history of partnering with Swiss academic institutions.
  • Focus on developing sustainable chemical processes.

Purpose of the Study:

  • To summarize successful academic-industry collaborations over the past decade.
  • To highlight the development of new synthetic routes, transformations, and reactor concepts.
  • To showcase the design and testing of novel catalysts with enhanced selectivity.

Main Methods:

  • Investigating a diverse range of chemical reactions and processes.
  • Collaborating with experts from Swiss academic institutions.
  • Designing, synthesizing, and testing new catalytic systems.
  • Probing the scope of existing catalytic systems.

Main Results:

  • Development of new synthetic routes for industrially relevant compounds.
  • Innovation in chemical transformations and reactor concepts.
  • Identification and creation of novel catalysts with improved selectivity.
  • Successful application of research findings in industrial settings.

Conclusions:

  • Collaborations between DSM Nutritional Products and Swiss academia have successfully advanced sustainable chemical process development.
  • New synthetic methodologies and catalytic systems have been established.
  • The research demonstrates a model for effective industry-academia partnerships in chemical innovation.