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Cardiovascular Health in Pediatric Rheumatologic Diseases

Kaveh Ardalan1, Donald M Lloyd-Jones2, Laura E Schanberg3

  • 1Department of Pediatrics, Division of Pediatric Rheumatology, Duke University School of Medicine, T909 Children's Health Center, DUMC Box 3212, Durham, NC 27710, USA; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago; Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago.

Rheumatic Diseases Clinics of North America
|November 20, 2021
PubMed

Insights

Children with rheumatic diseases like juvenile lupus face significant cardiovascular disease risk. Addressing inflammation and improving heart health through interventions is crucial for better long-term outcomes.

Area of Science:

  • Pediatric Rheumatology
  • Cardiovascular Health
  • Public Health

Background:

  • Children with juvenile systemic lupus erythematosus, juvenile dermatomyositis, and juvenile idiopathic arthritis exhibit increased cardiovascular disease risk.
  • Cardiovascular health, defined by the American Heart Association, encompasses protective factors against heart disease.
  • Chronic inflammation and endothelial dysfunction in rheumatic diseases contribute to elevated cardiovascular risk.

Purpose of the Study:

  • To highlight the cardiovascular disease risk in pediatric rheumatic diseases.
  • To emphasize the link between disease-related factors and cardiovascular health.
  • To underscore the need for interventions to improve cardiovascular outcomes in affected children.

Main Methods:

  • Literature review on cardiovascular risk in pediatric rheumatic diseases.
  • Analysis of the relationship between inflammation, endothelial dysfunction, and cardiovascular health.
  • Identification of gaps in current management strategies.

Main Results:

  • Juvenile rheumatic diseases are associated with early-onset cardiovascular disease risk.
  • Disease mechanisms directly and indirectly impair cardiovascular health.
  • Existing research indicates a need for targeted cardiovascular interventions.

Conclusions:

  • Children with juvenile idiopathic arthritis, juvenile dermatomyositis, and juvenile systemic lupus erythematosus require proactive cardiovascular risk management.
  • Interventions targeting chronic inflammation and endothelial dysfunction are essential.
  • Pharmacologic and nonpharmacologic strategies are needed to improve cardiovascular health and long-term outcomes in pediatric rheumatic diseases.

Keywords:
Cardiovascular diseaseCardiovascular healthJuvenile dermatomyositisJuvenile idiopathic arthritisPediatric rheumatologySystemic lupus erythematosus

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