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Inheritance of human-erythrocyte Gerbich blood group antigens
M E Reid1, C Sullivan, M Taylor
1Department of Laboratory Medicine, San Francisco General Hospital and Medical Center, CA 94110.
American Journal of Human Genetics
|December 1, 1987
Abstract:
The blood group-antigenic determinant Gerbich was first described greater than 25 years ago, but its mode of inheritance has not been established. We performed protein immunoblotting by means of anti-beta sialoglycoprotein (SGP) and anti-gamma SGP reagents. The anti-beta SGP was a monoclonal antibody that reacts with normal beta SGP and with the abnormal beta-related SGPs associated with Gerbich and Yus types of Ge-negative red cells. In the families studied, we have shown that the products of the Ge alleles are inherited in an autosomal codominant manner.