Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ogive Graph01:07

Ogive Graph

6.1K
An ogive graph is sometimes called a cumulative frequency polygon. It is one type of frequency polygon that shows cumulative frequency. In other words, the cumulative percentages are added to the graph from left to right. An ogive graph plots cumulative frequency on the vertical y-axis and class boundaries along the horizontal x-axis. It’s very similar to a histogram; only instead of rectangles, an ogive displays a single point where the top right of the rectangle would be. Creating this...
6.1K
Relative Frequency Histogram01:14

Relative Frequency Histogram

5.9K
The relative frequency depicts the proportion of data points that have each value. The frequency tells the number of data points that have each value. Like the histogram, a relative frequency histogram also has the same shape with a horizontal scale (the x-axis), but the vertical scale (the y-axis) is marked with relative frequencies (percentages of the whole) instead of actual frequencies. A relative frequency histogram is a graphical representation of a frequency distribution where the...
5.9K
Hardy-Weinberg Principle01:49

Hardy-Weinberg Principle

74.0K
Diploid organisms have two alleles of each gene, one from each parent, in their somatic cells. Therefore, each individual contributes two alleles to the gene pool of the population. The gene pool of a population is the sum of every allele of all genes within that population and has some degree of variation. Genetic variation is typically expressed as a relative frequency, which is the percentage of the total population that has a given allele, genotype or phenotype.
74.0K
Statistical Software for Data Analysis and Clinical Trials01:12

Statistical Software for Data Analysis and Clinical Trials

875
Statistical software is pivotal in data analysis and clinical trials by providing tools to analyze data, draw conclusions, and make predictions. These software packages range from simple data management applications to complex analytical platforms, supporting various statistical tests, models, and simulation techniques. Their significance lies in their ability to handle vast amounts of data with precision and efficiency, enabling researchers to validate hypotheses, identify trends, and make...
875
Biostatistics: Overview01:20

Biostatistics: Overview

405
Biostatistics plays a crucial role in understanding and analyzing data in healthcare and biology. Biostatisticians conduct experiments, gather evidence, and draw meaningful conclusions using statistical methods and techniques. Different variables form the foundation of biostatistical analysis, allowing researchers to understand and interpret data effectively. These variables are classified into different types, each serving a specific purpose in statistical analysis.
Discrete variables are...
405
Histogram01:05

Histogram

15.1K
The histogram is a graphical representation in the x-y form of data distribution in a data set. The horizontal x-axis is labeled with what the data represents (for instance, distance from your home to school). The vertical y-axis is labeled either frequency or relative frequency (or percent frequency or probability).
A histogram graph consists of contiguous (adjoining) boxes. The heights of the bars correspond to frequency values. The graph will have the same shape with respective labels. The...
15.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Donor Selection and Human Leukocyte Antigen Loss Leukemia Relapse After Hematopoietic Cell Transplantation.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2026
Same author

The Phenotype List String Grammar for Enhanced Protein and Antigen Reporting in the Immunogenetic Context.

HLA·2026
Same author

Advances in <i>MICA</i> genotyping: characterization of 406 novel alleles and their frequencies in multiple populations.

Frontiers in immunology·2026
Same author

Sustained HIV-1 remission after heterozygous CCR5Δ32 stem cell transplantation.

Nature·2025
Same author

PCR optimization for buccal swab-derived samples: overcoming sporadic inhibition with bovine serum albumin.

BMC genomics·2025
Same author

Young unrelated donors confer a survival advantage for patients with myeloid malignancies compared to older siblings.

Leukemia·2025
Same journal

The significance of galectin-9 and T-cell immunoglobulin and mucin domain-containing molecule-3 (TIM-3) in patients with chronic lymphocytic leukemia: The role of immune evasion.

Human immunology·2026
Same journal

The functional relevance of human leukocyte antigens in the development of cord blood derived advanced cellular therapies: A new direction of public cord blood banks.

Human immunology·2026
Same journal

From educational to graded: redefining proficiency testing in ABO genotyping.

Human immunology·2026
Same journal

Recurrent spontaneous abortion: integrated bioinformatics and histological validation identify FURIN and NEDD4 as ferroptosis-associated endometrial markers.

Human immunology·2026
Same journal

A perspective on ABO incompatible transplantation.

Human immunology·2026
Same journal

Classical HLA allele and haplotype frequency estimates in US populations.

Human immunology·2026
See all related articles

Related Experiment Video

Updated: Oct 12, 2025

A Femtoliter Droplet Array for Massively Parallel Protein Synthesis from Single DNA Molecules
10:45

A Femtoliter Droplet Array for Massively Parallel Protein Synthesis from Single DNA Molecules

Published on: June 20, 2020

10.5K

Graphical user interface for the haplotype frequency estimation software Hapl-o-Mat.

Ute V Solloch1, Alexander H Schmidt1, Jürgen Sauter1

  • 1DKMS, Tübingen, Germany.

Human Immunology
|November 20, 2021
PubMed
Summary
This summary is machine-generated.

Hapl-o-Mat, a tool for human leukocyte antigen (HLA) haplotype frequency estimation, now features a user-friendly interface and a Windows-compatible version. These updates aim to increase the availability of crucial HLA data for hematopoietic stem cell transplantation donor selection.

Keywords:
HLAHSCTHaplotype frequencies

More Related Videos

A Practical Guide to Phylogenetics for Nonexperts
12:00

A Practical Guide to Phylogenetics for Nonexperts

Published on: February 5, 2014

35.5K
Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
08:03

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

2.5K

Related Experiment Videos

Last Updated: Oct 12, 2025

A Femtoliter Droplet Array for Massively Parallel Protein Synthesis from Single DNA Molecules
10:45

A Femtoliter Droplet Array for Massively Parallel Protein Synthesis from Single DNA Molecules

Published on: June 20, 2020

10.5K
A Practical Guide to Phylogenetics for Nonexperts
12:00

A Practical Guide to Phylogenetics for Nonexperts

Published on: February 5, 2014

35.5K
Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
08:03

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

2.5K

Area of Science:

  • Immunogenetics
  • Computational Biology
  • Transplantation Science

Background:

  • Accurate human leukocyte antigen (HLA) haplotype frequencies are critical for optimizing donor selection in hematopoietic stem cell transplantation.
  • Existing tools for HLA haplotype frequency estimation may have limitations in accessibility and data handling.

Purpose of the Study:

  • To enhance the usability and accessibility of the Hapl-o-Mat software for estimating HLA haplotype frequencies.
  • To broaden the application of Hapl-o-Mat by researchers, thereby improving the public availability of population-specific HLA data.

Main Methods:

  • Development of a graphical user interface (GUI) module for Hapl-o-Mat to simplify user interaction.
  • Creation of a precompiled, standalone Windows version of Hapl-o-Mat, eliminating software library dependencies.
  • Continued use of the established expectation-maximization algorithm for haplotype frequency estimation.

Main Results:

  • Hapl-o-Mat now offers a more accessible and user-friendly experience through its new GUI.
  • A precompiled Windows version allows for straightforward implementation on personal computers.
  • These enhancements facilitate broader adoption and application of the tool by researchers.

Conclusions:

  • The updated Hapl-o-Mat, with its GUI and Windows binary, significantly lowers the barrier to entry for HLA haplotype frequency analysis.
  • Increased utilization of Hapl-o-Mat is expected to expand the knowledge base and public accessibility of population-specific HLA frequencies.
  • This advancement supports improved donor selection algorithms and enhances hematopoietic stem cell transplantation outcomes.