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Updated: Oct 12, 2025

Hemogenic Reprogramming of Human Fibroblasts by Enforced Expression of Transcription Factors
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Fibroblast transition to an endothelial "trans" state improves cell reprogramming efficiency

Megumi Mathison1, Deepthi Sanagasetti1, Vivek P Singh1

  • 1Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA.

Scientific Reports
|November 20, 2021
PubMed
Summary

Reprogramming fibroblasts into cardiomyocytes is enhanced by first inducing an endothelial cell state. This novel "trans-endothelial" approach improves cardiac cell regeneration potential.

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