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A proteome-wide map of 20(S)-hydroxycholesterol interactors in cell membranes

Yu-Shiuan Cheng1, Tianyi Zhang1, Xiang Ma1

  • 1Department of Chemistry, Division of Chemistry & Chemical Engineering, California Institute of Technology, Pasadena, CA, USA.

Nature Chemical Biology
|November 20, 2021
PubMed
Summary

Researchers developed a new chemoproteomics probe to map cellular interactions of 20(S)-hydroxycholesterol (20(S)-OHC). This study identifies key protein targets involved in immune response and cancer, revealing new therapeutic strategies.

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