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Updated: Oct 12, 2025
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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
Published on: February 7, 2021
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Subcutaneous Administration: Evolution, Challenges, and the Role of Hyaluronidase
1Seattle Cancer Care Alliance.
Clinical Journal of Oncology Nursing
|November 20, 2021
Summary
The subcutaneous (SC) route in oncology is expanding, with new therapies requiring higher volumes. Proper administration techniques and understanding anatomical sites are crucial for effective cancer treatment via SC injection.
Area of Science:
- Oncology
- Pharmacology
- Drug Delivery
Background:
- The subcutaneous (SC) route for chemotherapy and supportive therapies in oncology has significantly evolved.
- Numerous SC therapies are now approved, with some requiring higher volumes than previously established limits.
- Administration of newer SC drugs differs from traditional chemotherapy agents.
Purpose of the Study:
- To provide a historical overview of the SC route in cancer treatment.
- To describe the current role of SC administration in oncology.
- To review the use of recombinant hyaluronidase with SC monoclonal antibodies and discuss administration techniques.
Main Methods:
- A review of sentinel medical texts.
- Analysis of pharmacokinetic studies.
- Examination of manufacturer's recommendations and peer-reviewed articles.
Main Results:
- The SC route presents advantages over oral and intravenous (IV) administration.
- Understanding SC injection sites and techniques is vital for patient education.
- Recombinant hyaluronidase facilitates SC administration of monoclonal antibodies.
Conclusions:
- The SC route is a viable and evolving option for cancer therapy delivery.
- Optimizing SC administration requires knowledge of anatomy and technique.
- Patient education on SC injection is essential for successful treatment outcomes.
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