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RIFM fragrance ingredient safety assessment, anisole, CAS Registry Number 100-66-3

A M Api1, D Belsito2, D Botelho1

  • 1Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
|November 20, 2021
PubMed
Summary

No abstract available in PubMed .

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Secondary amines react with nitrous acid to form N-nitrosamines, as depicted in Figure 1. Nitrous acid, a weak and unstable acid, is formed in situ from an aqueous solution of sodium nitrite and strong acids, such as hydrochloric acid or sulfuric acid, in cold conditions. In the presence of an acid, the nitrous acid gets protonated. The subsequent loss of water results in the formation of the electrophile known as nitrosonium ion.