Related Experiment Video

Updated: Oct 12, 2025

Glycan Node Analysis: A Bottom-up Approach to Glycomics
11:36

Glycan Node Analysis: A Bottom-up Approach to Glycomics

Published on: May 22, 2016

10.7K

O-GlcNAcylation regulation of cellular signaling in cancer

Lorela Ciraku1, Emily M Esquea1, Mauricio J Reginato2

  • 1Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA, USA.

Cellular Signalling
|November 20, 2021
PubMed

Insights

O-GlcNAcylation, a nutrient-sensing modification, impacts protein function and cancer signaling. Elevated O-GlcNAcylation regulates cancer pathways and immune responses, highlighting its critical role in oncology.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cancer Research

Background:

  • O-GlcNAcylation is a dynamic post-translational modification on serine/threonine residues.
  • It is regulated by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA).
  • O-GlcNAcylation influences protein stability, interactions, and phosphorylation, acting as a nutrient sensor.

Purpose of the Study:

  • To review recent findings on O-GlcNAcylation in cancer.
  • To explore its role as a metabolic sensor in cancer signaling pathways.
  • To discuss its involvement in the immune response within the tumor microenvironment.

Main Methods:

  • Literature review of recent studies on O-GlcNAcylation and cancer.
  • Analysis of the regulatory mechanisms of OGT and OGA in cancer.
  • Examination of O-GlcNAcylation's impact on key cancer signaling pathways.

Main Results:

  • Elevated OGT and O-GlcNAc levels are observed in various cancers.
  • O-GlcNAcylation modulates critical cancer-related signaling pathways.
  • This modification influences the anti-tumor immune response.

Conclusions:

  • O-GlcNAcylation is a key player in cancer development and progression.
  • Targeting O-GlcNAcylation pathways presents potential therapeutic strategies for cancer.
  • Further research is needed to fully elucidate its complex roles in cancer biology.
Keywords:
MetabolismO-GlcNAcOGTSignalingTranscriptioncancer

More Related Videos

Analysis of SCAP N-glycosylation and Trafficking in Human Cells11:27

Analysis of SCAP N-glycosylation and Trafficking in Human Cells

Published on: November 8, 2016

8.9K
Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line06:24

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

Published on: April 11, 2025

606

Related Concept Videos

mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.9K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.6K
Amplifying Signals via Enzymatic Cascade01:22

Amplifying Signals via Enzymatic Cascade

When a ligand binds to a cell-surface receptor, the receptor's intracellular domain changes shape, which may either activate its enzyme function or allow its binding to other molecules. The initial signal is amplified by most signal transduction pathways. This means that a single ligand molecule can activate multiple molecules of a downstream target. Proteins that relay a signal are most commonly phosphorylated at one or more sites, activating or inactivating the protein. Kinases catalyze...
13.3K
PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
4.1K
The Ras Gene02:38

The Ras Gene

The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a...
6.5K
GPCRs Regulate Adenylyl Cylase Activity01:09

GPCRs Regulate Adenylyl Cylase Activity

Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of...
6.1K