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In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
Published on: February 16, 2016
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Normal Ranges of Global Left Ventricular Myocardial Work Indices in Adults: A Meta-Analysis
Vien T Truong1, Ha Q Vo2, Tam N M Ngo3
1The Christ Hospital Health Network, Cincinnati, Ohio; The Linder Research Center, Cincinnati, Ohio.
Summary
This meta-analysis establishes normal ranges for noninvasive myocardial work (MW) indices. These values, including global work index and efficiency, aid in clinical diagnosis and research.
Area of Science:
- Cardiology
- Echocardiography
- Biomedical Engineering
Background:
- Left ventricular myocardial work (MW) offers diagnostic and prognostic value beyond ejection fraction and strain.
- Noninvasive MW indices are increasingly recognized for their clinical utility.
- Understanding normal MW ranges is crucial for accurate interpretation.
Purpose of the Study:
- To perform a meta-analysis of normal ranges for noninvasive left ventricular myocardial work (MW) indices.
- To identify confounders affecting reported MW values.
- To provide reference ranges for global work index, global constructive work, global wasted work, and global work efficiency.
Main Methods:
- A systematic search of four databases (PubMed, Scopus, Embase, Cochrane Library) was conducted through January 2021.
- Included studies reported LV MW using 2D transthoracic echocardiography in healthy subjects.
- Random-effect models were used to estimate weighted means and 95% CIs; heterogeneity and publication bias were assessed.
Main Results:
- 13 datasets with 1,665 patients were included in the meta-analysis.
- Normal mean values: Global Work Index 2,010 mm Hg%, Global Constructive Work 2,278 mm Hg%, Global Wasted Work 80 mm Hg%, Global Work Efficiency 96.0%.
- Gender was a significant confounder for global work index, global wasted work, and global work efficiency.
Conclusions:
- This meta-analysis provides echocardiographic reference ranges for noninvasive MW indices.
- These established normal values can be utilized in clinical practice and research.
- The findings support the use of MW indices for improved cardiovascular assessment.
