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Immunohistochemical studies of lymph nodes from LAS and AIDS patients
1Zentrum der Pathologie, J.W. Goethe Universität, Frankfurt, Federal Republic of Germany.
Cancer Detection and Prevention. Supplement : Official Publication of the International Society for Preventive Oncology, Inc
|January 1, 1987
Abstract:
Lymph nodes from eight LAS and six AIDS patients were studied by routine histology, immunohistochemistry, and ultraimmunohistochemistry. LAS lymph nodes show a peculiar follicular hyperplasia with a characteristic increase of proliferating dendritic and interdigitating reticulum cells. In AIDS, these cells are reduced and the expression of proliferation-associated antigens is diminished. The immunohistochemical analysis of dendritic and interdigitating reticulum cells and of proliferation-associated antigens in lymph nodes thus allows a clear distinction between LAS and AIDS and may have important prognostic implications.