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Related Experiment Video

Updated: Oct 12, 2025

Whole-animal Imaging and Flow Cytometric Techniques for Analysis of Antigen-specific CD8+ T Cell Responses after Nanoparticle Vaccination

Whole-animal Imaging and Flow Cytometric Techniques for Analysis of Antigen-specific CD8+ T Cell Responses after Nanoparticle Vaccination

Published on: April 29, 2015

Current and future nanoparticle vaccines for COVID-19.

Mai N Vu¹, Hannah G Kelly², Stephen J Kent³

¹Peter Doherty Institute for Infection and Immunity, Department of Microbiology and Immunology, University of Melbourne, Melbourne, VIC 3000, Australia; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Parkville, VIC 3052, Australia; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia; Department of Pharmaceutics, Hanoi University of Pharmacy, Hanoi 10000, Vietnam.

|November 21, 2021

Summary

Nanoparticle vaccines offer a promising new approach to combat COVID-19, with many candidates in development. These advanced platforms aim to improve vaccination outcomes against the SARS-CoV-2 virus.

Keywords:

COVID-19 vaccine SARS-CoV-2 nanoparticle vaccine neutralizing antibody protein nanoparticle

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Whole-animal Imaging and Flow Cytometric Techniques for Analysis of Antigen-specific CD8+ T Cell Responses after Nanoparticle Vaccination

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Published on: August 21, 2019

Area of Science:

Vaccinology
Nanotechnology
Infectious Disease Research

Background:

COVID-19 pandemic caused significant global mortality and socioeconomic disruption.
Mass vaccination is crucial for pandemic control.
First-generation vaccines (mRNA, viral vector) were rapidly developed.

Purpose of the Study:

To discuss the role of nanotechnology in developing novel SARS-CoV-2 vaccines.
To highlight the potential of nanoparticle vaccine candidates.
To outline opportunities and challenges in this field.

Main Methods:

Review of emerging nanoparticle vaccine candidates for COVID-19.
Discussion of nanotechnology applications in vaccine design and manufacturing.
Analysis of clinical and pre-clinical development stages.

Main Results:

Over 26 nanoparticle vaccine candidates are in clinical trials, with approximately 60 in pre-clinical development.
Nanoparticle platforms show potential for enhancing vaccine efficacy.
These novel platforms present unique manufacturing and deployment considerations.

Conclusions:

Nanoparticle-based vaccines are poised to play a significant role in future COVID-19 vaccination strategies.
Continued research and development are essential to overcome challenges associated with these advanced platforms.
Nanotechnology offers a pathway to improved and extended vaccination outcomes against SARS-CoV-2.