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Splenic function in chronic myelogenous leukemia.

D T Covas1, M A Zago

  • 1Department of Clinical Medicine, School of Medicine of Ribeirão Preto, Brazil.

European Journal of Haematology
|November 1, 1987
PubMed
Summary
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Patients with chronic myelogenous leukemia (CML) show normal spleen function despite enlarged spleens. This indicates reduced spleen function per volume, suggesting splenic hypofunction in CML patients.

Area of Science:

  • Hematology
  • Nuclear Medicine
  • Pathophysiology

Background:

  • Spleen size and function are critical in hematological disorders.
  • Chronic myelogenous leukemia (CML) often presents with splenomegaly.

Purpose of the Study:

  • To evaluate spleen function and volume in patients with CML.
  • To compare CML spleen function with normal controls, splenectomized subjects, and reactive splenomegaly.

Main Methods:

  • Assessed spleen function via clearance of 99mTc-labelled heat-damaged erythrocytes.
  • Enumerated pitted erythrocytes using interference contrast microscopy.
  • Determined spleen area using scintillation scanning.

Main Results:

  • Patients with CML exhibited enlarged spleens comparable in size to those with reactive splenomegaly.

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  • Spleen function test results in CML patients were similar to normal controls.
  • A decreased spleen function per unit volume was observed in CML patients, alongside peripheral blood signs of splenic hypofunction.

    • Conclusions:

    • CML is characterized by reduced spleen function per volume, likely due to decreased splenic blood perfusion.
    • Myeloid metaplasia and increased blood viscosity contribute to impaired spleen perfusion in CML.
    • Findings suggest splenic hypofunction in CML, despite normal overall spleen function tests.