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Updated: Oct 12, 2025

Underwater Endoscopic Injection Sclerotherapy for Gastroesophageal Varices
Published on: August 1, 2025
Endoscopic Treatment of Gastric and Ectopic Varices
Roberto Oleas1, Carlos Robles-Medranda1
1Instituto Ecuatoriano de Enfermedades Digestivas, Torre Vitalis I, Mezzanine 3, Av. Abel Romeo S/N y Av. Juan Tanca Marengo, Guayaquil 090505, Ecuador.
Abstract:
Gastric variceal bleeding has a high mortality. Endoscopic cyanoacrylate injection is the standard therapy; however, rebleeding and unexpected adverse events, such as injection sites ulcers and distal glue embolisms, are pitfalls of this therapy. Endoscopic ultrasound (EUS)-guided endovascular therapies offer a safer and more practical alternative for the treatment of gastric varices. EUS-guided combined therapy with coiling and cyanoacrylate injection is the most promising alternative with high obliteration rates and fewer adverse events reported. The authors reviewed the latest available data for all endoscopic therapies proposed for the management of gastric varices in patients with chronic liver disease.
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