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Related Experiment Videos

Growth hormone and experimental cancer cachexia.

G Svaninger1, O Isaksson, K Lundholm

  • 1Department of Surgery, University of Gothenburg, Sahlgrenska Hospital, Sweden.

Journal of the National Cancer Institute
|December 1, 1987
PubMed
Summary

In tumor-bearing mice, elevated growth hormone (GH) levels result from malnutrition, not the tumor itself. GH treatment did not improve muscle wasting or body composition in these animals.

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Area of Science:

  • Endocrinology
  • Oncology
  • Animal Models

Background:

  • Elevated plasma growth hormone (GH) levels are observed in various disease states, including cancer.
  • The role of GH in cancer cachexia and host metabolism requires further elucidation.

Purpose of the Study:

  • To investigate plasma GH levels in adult sarcoma-bearing mice.
  • To evaluate the effects of GH treatment on host body composition and tumor growth in different animal models.

Main Methods:

  • Measurements of plasma GH levels in adult C57BL/6J mice with sarcoma.
  • Administration of exogenous GH to tumor-bearing mice, tumor-bearing hypophysectomized rats, and malnourished non-tumor-bearing animals.
  • Assessment of host body composition, muscle wasting, and tumor growth.

Main Results:

  • Sarcoma-bearing mice exhibited increased plasma GH levels, correlating with tumor progression and malnutrition.
  • GH treatment did not improve muscle wasting or body composition in tumor-bearing hosts.
  • Exogenous GH supported host body growth and tumor growth equally in hypophysectomized rats.

Conclusions:

  • Malnutrition and anorexia, rather than the tumor itself, are primary drivers of elevated GH in tumor-bearing hosts.
  • GH supplementation is unlikely to benefit freely eating tumor-bearing hosts by replenishing host tissues.
  • GH may play a role in preventing substrate deficiency and hypoglycemia in tumor-bearing animals.

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