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Chronic Hepatitis B Infection Among Preexposure Prophylaxis Users Enrolled in a Population-Based Program in British

Kyle A Thompson1, Gabriel Blank2, Junine Toy1

  • 1BC Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.

Open Forum Infectious Diseases
|November 22, 2021
PubMed

Insights

Initiating pre-exposure prophylaxis (PrEP) for HIV also treats hepatitis B virus (HBV) infection. However, many patients in a Canadian PrEP program lacked necessary HBV DNA monitoring, highlighting a need for prescriber education.

Area of Science:

  • Infectious Diseases
  • Hepatology
  • Public Health

Background:

  • Hepatitis B virus (HBV) infection is a significant global health concern.
  • Pre-exposure prophylaxis (PrEP) is a critical tool for human immunodeficiency virus (HIV) prevention.
  • Certain antiretroviral medications used in PrEP have demonstrated activity against HBV.

Purpose of the Study:

  • To determine the prevalence of chronic hepatitis B virus (HBV) infection among individuals enrolling in a provincial pre-exposure prophylaxis (PrEP) program.
  • To assess the adequacy of HBV DNA monitoring for patients with chronic HBV within the PrEP program.
  • To identify educational needs for healthcare providers prescribing PrEP regarding HBV co-infection management.

Main Methods:

  • Retrospective analysis of patient data from a provincial PrEP program in British Columbia, Canada.
  • Calculation of the prevalence of chronic HBV infection among program enrollees.
  • Review of medical records to determine the proportion of patients with chronic HBV who received HBV DNA monitoring.

Main Results:

  • The prevalence of chronic HBV infection was 0.86% (41 out of 4760) among PrEP program participants.
  • A significant proportion, 46.3%, of individuals with chronic HBV lacked follow-up HBV DNA monitoring.
  • This indicates a gap in the management of HBV in this patient population.

Conclusions:

  • Initiation of PrEP for HIV prevention can concurrently treat chronic HBV infection.
  • There is a critical need for improved HBV-related education for healthcare providers who prescribe PrEP.
  • Enhanced prescriber education is essential to ensure adequate HBV monitoring and management in individuals on PrEP.

Keywords:
HIV PrEPHIV preventionMSMemtricitabine/tenofovir disoproxil fumaratehepatitis B

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