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Micro-scale Engineering for Cell Biology
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Introduction.

Jaroslava Halper1

  • 1Department of Pathology, College of Veterinary Medicine, and Department of Basic Sciences, AU/UGA Medical Partnership, The University of Georgia, Athens, GA, USA. jhalper@uga.edu.

Advances in Experimental Medicine and Biology
|November 22, 2021
PubMed
Summary

This book update covers heritable soft connective tissue diseases, including new syndromes and updated knowledge on connective tissue components like collagen and tendon function.

Keywords:
Collagen VI myopathiesCollagen and tendon structure and functionCutis laxaEhlers- Danlos syndromeJoint hypermobilityMarfan syndromeTransforming growth factor β

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Micro-scale Engineering for Cell Biology
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Area of Science:

  • Genetics and Molecular Biology
  • Rheumatology
  • Pathology

Background:

  • Heritable soft connective tissue diseases encompass a range of disorders affecting connective tissues.
  • Understanding the pathophysiology and clinical manifestations is crucial for diagnosis and management.
  • Previous knowledge requires regular updates due to ongoing research.

Purpose of the Study:

  • To provide the latest updates on the pathophysiology, pathology, clinical presentation, and treatment of heritable soft connective tissue diseases.
  • To incorporate new knowledge regarding the structure and function of connective tissue components, such as collagen.
  • To detail newly identified syndromes and subgroups of existing disorders.

Main Methods:

  • This section is not applicable as the abstract describes a book update, not a specific study.
  • The content is based on the synthesis of current research and expert knowledge by prominent investigators.
  • Information is presented through detailed textual explanations and potentially illustrative examples.

Main Results:

  • The second edition offers updated information on the pathophysiology, pathology, clinical presentation, and treatment of these diseases.
  • New insights into the structure and function of basic connective tissue components (e.g., collagen) and organs (e.g., tendons) are included.
  • Novel syndromes and new subgroups of previously described disorders are presented.

Conclusions:

  • The updated edition serves as a comprehensive resource for understanding heritable soft connective tissue diseases.
  • It integrates recent advancements in the field, offering valuable knowledge for researchers and clinicians.
  • The book's clarity and the authors' expertise enhance its utility for interested readers.