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Sinus histiocytosis with massive lymphadenopathy
1Diagnostic Radiology Department, National Cancer Institute, Bethesda, Maryland 20892.
Clinical Nuclear Medicine
|November 1, 1987
Summary
This study reports gallium uptake correlating with disease extent in a patient with sinus histiocytosis with massive lymphadenopathy (SHML). Imaging revealed extensive orbital, maxillary, and retropharyngeal tumor involvement.
Area of Science:
- Oncology
- Nuclear Medicine
- Radiology
Background:
- Sinus histiocytosis with massive lymphadenopathy (SHML), also known as Rosai-Dorfman disease, is a rare benign condition characterized by lymphadenopathy and histiocytic infiltration.
- Orbital and head and neck manifestations of SHML are uncommon but can lead to significant morbidity.
Observation:
- A case of histologically confirmed SHML is presented with detailed imaging findings.
- Computerized tomography (CT) demonstrated bilateral retrobulbar masses and involvement of the lateral recti muscles.
- Further CT findings included erosion of the orbital floor, tumor extension into the right maxillary antrum, and retropharyngeal lymphadenopathy.
Findings:
- Gallium-67 citrate scintigraphy revealed uptake that corresponded directly with the extent and location of the documented disease.
- The gallium uptake pattern accurately reflected the widespread nature of the SHML, including orbital, maxillary, and retropharyngeal sites.
Implications:
- Gallium scintigraphy may serve as a valuable non-invasive tool for assessing disease extent and monitoring treatment response in SHML, particularly in complex head and neck presentations.
- This case highlights the importance of comprehensive imaging in diagnosing and managing SHML, especially when it involves critical structures like the orbit and airway.
- Further research into the role of nuclear imaging in SHML could optimize diagnostic and therapeutic strategies for this rare condition.